Marvel Strike Teams puts players in the role of some of their favorite Marvel Universe heroes and villains. Two to five players face off in a classic battle of good versus evil. Everyone gets a character with a HeroClix combat dial to track their level and build points. One player is the villainous mastermind and is able to guide the direction of each encounter; the rest are the heroes who each control a single hero for the mission and must work together by combining their vast array of powers and abilities to complete various objectives, such as infiltrating an enemy warehouse or saving hostages.